MICROGLIA RAGE EXACERBATES THE PROGRESSION OF NEURODEGENERATION WITHIN THE SOD1 G93A MURINE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS IN A SEX-DEPENDENT MANNER

Abstract Background Burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS).The receptor for advanced glycation end products (RAGE) binds ligands relevant to ALS that accumulate in the diseased spinal cord and RAGE has been previously implicated in th

BackgroundThe aim of this study was to understand online public perceptions of the debate surrounding the choice of annual influenza vaccinations or wearing masks as a condition of employment for healthcare workers, such as the one enacted in British Columbia in August 2012.MethodsFour national and 82 local (British Columbia) Canadian online news s

Caenorhabditis elegans neurons under stress can produce giant vesicles, several microns in diameter, called exophers.Current models suggest that exophers are neuroprotective, providing a mechanism for stressed neurons to eject toxic protein aggregates and organelles.However, little is known of the fate of the exopher once it leaves the neuron.We fo

Azimuth propulsion systems (azipods, screw-steering columns, SSC) are widely used on new types of vessels intended for the implementation of large-scale projects for the integrated development of the Northern Sea Route.The main way to study the operation of such vessels is their mathematical modeling with the inclusion in the model of both the hull